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Daniel C Maneval Selected Research

PEGPH20

11/2022Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy.
1/2021Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non-small cell lung cancer.
11/2019The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44.
10/2018Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression.
1/2018Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.

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Daniel C Maneval Research Topics

Disease

9Neoplasms (Cancer)
09/2023 - 02/2002
4Urinary Bladder Neoplasms (Bladder Cancer)
09/2013 - 02/2002
2Pancreatic Neoplasms (Pancreatic Cancer)
10/2018 - 01/2013
1Lung Neoplasms (Lung Cancer)
09/2023
1Adenocarcinoma
11/2022
1Neoplasm Metastasis (Metastasis)
11/2022
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021
1Hypotension (Low Blood Pressure)
01/2020
1Pain (Aches)
01/2020
1Breast Neoplasms (Breast Cancer)
11/2019
1Hypoxia (Hypoxemia)
10/2018
1Nausea
02/2014
1Vomiting
02/2014
1Glaucoma
12/2004
1Body Weight (Weight, Body)
04/2002
1Brain Neoplasms (Brain Tumor)
03/2002

Drug/Important Bio-Agent (IBA)

5Hyaluronic Acid (Hyaluronan)IBA
11/2022 - 01/2013
5PEGPH20IBA
11/2022 - 01/2018
4Hyaluronoglucosaminidase (Hyaluronidase)FDA Link
11/2022 - 02/2014
1GemcitabineFDA Link
09/2023
1AlbuminsIBA
09/2023
1Focal Adhesion Protein-Tyrosine KinasesIBA
11/2022
1Programmed Cell Death 1 ReceptorIBA
11/2022
1Docetaxel (Taxotere)FDA Link
01/2021
1Small Interfering RNA (siRNA)IBA
11/2019
1Hyaluronan SynthasesIBA
11/2019
1CytokinesIBA
10/2018
1CollagenIBA
10/2018
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2018
1Ondansetron (Zofran)FDA LinkGeneric
02/2014
1Excipients (Suspending Agents)IBA
09/2013
1Viral DNAIBA
11/2004
1Proteins (Proteins, Gene)FDA Link
09/2004
1CaspasesIBA
09/2004
1InterferonsIBA
09/2004
1Green Fluorescent ProteinsIBA
09/2004
1Icodextrin (Extraneal)FDA Link
04/2003
1adenovirus receptorIBA
08/2002
1Nylons (Nylon)IBA
08/2002
1beta-Galactosidase (Lactaid)IBA
08/2002
1Biomarkers (Surrogate Marker)IBA
02/2002

Therapy/Procedure

2Therapeutics
11/2022 - 01/2018
2Intravenous Administration
11/2004 - 04/2002
1Catheters
01/2020
1Aftercare (After-Treatment)
09/2013
1Filtering Surgery
12/2004
1Intra-Arterial Infusions
03/2002
1Intravesical Administration
02/2002
1Cystectomy
02/2002